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HK J Paediatr (New Series)
Vol 19. No. 2,
2014
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HK J Paediatr (New Series) 2014;19:71-74
Original Article
An Examination of the Effects of Phenobarbital on Thyroid Function Tests in Childhood Epilepsy
A Cayir, MI Turan, IS Esin Department of Pediatric Endocrinology, Ataturk University, Faculty of Medicine, Erzurum, Turkey A Cayir MD Department of Pediatric Neurology, Ataturk University, Faculty of Medicine, Erzurum, Turkey MI Turan MD Department of Child and Adolescent Psychiatry, Ataturk University, Faculty of Medicine, Erzurum, Turkey IS Esin MD Correspondence to: Dr A Cayir Received June 23, 2013
Abstract Aim: The aim of this study was to evaluate changes in thyroid function tests in a group of epileptic children taking phenobarbital. Materials and Methods: Patients' demographic data and free thyroxine (FT4), free triiodothyronine (FT3) and thyroid-stimulating hormone (TSH) levels during at least 12 months of treatment were recorded. Forty-eight children using phenobarbital and 45 healthy children were enrolled. Results: In the phenobarbital group, FT3 level was 4.14±0.1 pg/mL, FT4 1.22±0.01 ng/dL and TSH 2.88±0.21 mIU/L. In the control group, FT3 level was 4.28±0.08 pg/mL, FT4 1.34±0.02 ng/dL and TSH 2.28±0.19 mIU/L. The rates of subclinical hypothyroidism between the two groups were not show statistically significant difference (p=0.16). Conclusion: The use of phenobarbital in the treatment of childhood epilepsy does not appear to increase the risk of thyroid dysfunction. Keyword : Child; Epilepsy; Phenobarbital; Thyroid function test
Abstract in Chinese
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