Table of Contents

HK J Paediatr (New Series)
Vol 19. No. 1, 2014

HK J Paediatr (New Series) 2014;19:22-27

Original Article

The Relationship between Glycosylated Haemoglobin (HbA1c) Levels and Serum Lipid Profiles in Insulin Resistant Children

ZE Önal, V Atasayan, N Akici, T Gürbüz, Ç Nuhoğlu


Purpose: We aimed to evaluate the impact of glycaemic control on serum lipid profiles in children according to their insulin resistance screened by homeostasis model assessment (HOMA-IR) levels. Methods: This study included 130 children, aged between 3 and 15 years old who were admitted to our clinic with upper respiratory infection symptomps. We analysed their anthropometric measures, serum glycosylated haemoglobin (HbA1c) levels. Insulin resistance was estimated by HOMA-IR. Serum total cholesterol, high density lipoprotein-cholesterol (HDL-C), low density lipoprotein-cholesterol (LDL- C) and triglyceride levels were analysed. Findings: When serum HDL-C levels of insulin resistant group with HOMA-IR ≥3.5 were significantly lower, triglyceride levels were significantly higher, compared to the non-resistant group with HOMA-IR <3.5. Serum HDL-C, LDL-C, total cholesterol and triglyceride levels did not correlate with HbA1c levels among the insulin resistant group with HOMA-IR ≥3.5 and irresistant group with HOMA-IR <3.5. Conclusions: Insulin resistance status was directly associated with higher serum triglyceride and lower HDL-C levels, however HbA1c levels reflecting glycaemic status did not reveal an association with serum lipid profiles among insulin resistant children with HOMA-IR ≥3.5 levels.

目的:穩態模式評估法測量胰島素抗性兒童,以評估兒童血糖控制對血脂肪水平的影響。方法:這項研究對象為130名年齡介乎3至15歲因上呼吸道感染而到門診就診的兒童。分析他們體內的測量學數據,血糖化血紅蛋白水平。穩態模式評估法測量胰島素抗性。血清總膽固醇,高密度脂蛋白,低密度脂蛋白,甘油三脂水平。結果:對比穩態模式評估法<3.5的非胰島素抗性組,當穩態模式評估法≥3.5的胰島素抗性組血清高密度脂蛋白明顯性降低時,甘油三脂水平明顯升高。血高密度脂蛋白,低密度脂蛋白和甘油三脂水平在胰島素抗性組和非胰島素抗性組中均與糖化血紅蛋白水平不相關。結論:胰島素抗性狀態與增高的血甘油三酯和降低的高密度脂蛋白水平有直接的關係。但是,反映血糖狀況的糖化血紅蛋白水平,則不能顯示血脂肪水平與穩態模式評估法 ≥3.5的胰島素抗性患兒的關係。

Keyword : Child; Haemoglobin A1c protein; Insulin resistance; Lipids



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