ZE Önal, V Atasayan, N Akici, T Gürbüz, Ç Nuhoğlu

Abstract

Purpose: We aimed to evaluate the impact of glycaemic control on serum lipid profiles in children according to their insulin resistance screened by homeostasis model assessment (HOMA-IR) levels. Methods: This study included 130 children, aged between 3 and 15 years old who were admitted to our clinic with upper respiratory infection symptomps. We analysed their anthropometric measures, serum glycosylated haemoglobin (HbA1c) levels. Insulin resistance was estimated by HOMA-IR. Serum total cholesterol, high density lipoprotein-cholesterol (HDL-C), low density lipoprotein-cholesterol (LDL- C) and triglyceride levels were analysed. Findings: When serum HDL-C levels of insulin resistant group with HOMA-IR ≥3.5 were significantly lower, triglyceride levels were significantly higher, compared to the non-resistant group with HOMA-IR <3.5. Serum HDL-C, LDL-C, total cholesterol and triglyceride levels did not correlate with HbA1c levels among the insulin resistant group with HOMA-IR ≥3.5 and irresistant group with HOMA-IR <3.5. Conclusions: Insulin resistance status was directly associated with higher serum triglyceride and lower HDL-C levels, however HbA1c levels reflecting glycaemic status did not reveal an association with serum lipid profiles among insulin resistant children with HOMA-IR ≥3.5 levels.