Table of Contents

HK J Paediatr (New Series)
Vol 18. No. 3, 2013

HK J Paediatr (New Series) 2013;18:152-158

Original Article

Short Sleep Duration as a Risk Factor for Obesity in Childhood Is Associated with Increased Leptin, Ghrelin, and Orexin Levels

JF Fu, F Zhou, XQ Xu, CC Zou, CL Wang, K Huang, L Liang


Objectives: To explore the association between short sleep duration, obesity and the role of appetite-related hormones in 10 to 15 years old children. Design: An observational study was conducted from January 2003 to June 2010, with epidemiological survey, anthropometry, and laboratory tests. One-way logistic and linear logistic methods were used for data analysis. Participants: A total of 311 obese children aged from 10 to 15 years and 300 healthy children with normal body mass index at the equivalent ages. Measurements and Results: Life styles of all participants were surveyed by questionnaires. Fasting serum samples were collected for detection of leptin, ghrelin and orexin from 114 obese and 49 healthy children randomly selected from the patient pool. Sleep duration of obese children, usually less than 9 hours, was 1 hour shorter than that of the healthy controls (P<0.05). Compared to the children sleeping less than 8 hours, the odd ratio for susceptibility to obesity was 0.015 (95% confidence interval: 0.005-0.051) for those sleeping more than 10 hours. Linear regression revealed that shorter sleep was associated with higher serum leptin, ghrelin, and orexin levels. If children's sleep time was deprived by one hour, the level of leptin, ghrelin and orexin will increase 7.894 ng/ml, 21.716 ng/ml, and 2.409 ng/ml respectively (P<0.01). Conclusions: Children at the age of 10 to 15 years have short sleep in common and those who do not sleep sufficiently are susceptible to obesity. Serum leptin, ghrelin, and orexin levels in children were elevated when they sleep less and consequently this increased the risk of obesity.

目的:探討在10-15歲兒童中,睡眠時間短促與肥胖、食慾相關激素之間的相關性。設計:2003年1月至2010年 6月之間開展了一項觀察性研究和流行病學調查、人體測量學以及實驗室檢測。利用單向邏輯和線性邏輯方法進行資料分析。參與者:311名10-15歲的肥胖兒童,以及300名年齡相若、BMI正常的健康兒童。測量和結果:透過問卷調查所有參與者的生活方式。隨機抽取114名肥胖兒童和49名健康兒童,收集空腹血標本檢測瘦素、饑餓素和食慾素水平。肥胖兒童的睡眠時間通常少於9小時,比健康兒童少1個小時(P<0.05)。與睡眠時間少於8個小時的兒童相比,睡眠時間超過10個小時的兒童易患肥胖的比值比為0.015(95%置信區間:0.005-0.05)。線性回歸分析顯示睡眠時間短與血清瘦素、饑餓素和食慾素水平升高有關:如果剝奪兒童睡眠時間1個小時,瘦素、饑餓素和食慾素水平會分別升高7.894 ng/ml, 21.716 ng/ml和 2.409 ng/ml (P<0.01)。結論:10-15歲兒童通睡眠時間短。睡眠時間不足兒童易患肥胖。當兒童睡眠時間少,血清瘦素、饑餓素和食慾素水平增高,從而增加出現肥胖的機會。

Keyword : Body mass index; Ghrelin; Leptin; Obesity, childhood; Orexin; Short sleep duration



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