M Mutlu, A Çayir, Y Çayir, B Özkan, Y Aslan

Abstract

Objectives: Low antioxidant system may contribute to the severity of neonatal hyperbilirubinaemia. This study was performed with the aim of establishing whether there is a relationship between serum vitamin D level and the hyperbilirubinaemia in full-term neonates. Material and methods: This prospective study was performed by comparing serum vitamin D levels in newborns with a pathological level of hyperbilirubinaemia and healthy newborns with a physiological level of hyperbilirubinaemia or without jaundice. Ethical committee approval was obtained and written informed consent forms were received from babies' families. Results: A statistically significant difference was found in the serum 25-hydroxy vitamin D levels between newborns with hyperbilirubinaemia and control group (p=0.01). A significant negative correlation was noted between serum vitamin D and serum parathyroid hormone levels among the neonates recruited (r:-0.3, p:0.03). Conclusions: Our results suggest that low level of serum vitamin D may associate with hyperbilirubinaemia in full-term neonates.

目標：抗氧化系統功能低下，可能會導致嚴重的新生兒高膽紅素血症。進行這項研究旨在確定足月新生兒高膽紅素血症是否與血清維生素D水平有關。方法：本前瞻性研究比較了病理性新生兒高膽紅素血症患兒和健康生理性新生兒高膽紅素血症或無黃疸嬰兒的血清維生素D水平。獲得倫理委員會批准，從嬰兒的家人獲取書面知情同意書。結果：發現新生兒高膽紅素血症和對照組，在血清25-羥基維生素D水平（p=0.01）有統計學差異。並指出新生兒血清維生素D和血清甲狀旁腺激素水平之間存在顯著的負相關係（r:-0.3,p:0.03）。結論：我們的研究結果表明，低血清維生素D水平可能與足月新生兒高膽紅素血症有關。