Table of Contents

HK J Paediatr (New Series)
Vol 18. No. 2, 2013

HK J Paediatr (New Series) 2013;18:63-68

Original Article

Erythromycin Improves Symptoms and Electrogastrographic Patterns of Children with Dyspepsia

MWY Leung, NSY Chao, KKW Liu


Purpose: Erythromycin is a prokinetic agent which enhances gastric smooth muscle contraction. In this study, we investigate the effect of short term erythromycin on children having dyspepsia symptoms. Methods: Eight children aged 7-18 with persistent dyspeptic symptoms were recruited. They all had abnormal dyspeptic symptom scores and electrogastrographic (EGG) patterns. All children were given erythromycin suspension 2 mg/kg thrice daily for 2 weeks. Results: All 8 children completed the 2-week course of erythromycin. Mean dyspepsia symptom scores before and after treatment were 6.75 and 4.63 respectively (p=0.025). Mean normogastria time in EGG before and after treatment were 65.87% and 77.58% respectively (p=0.012). After erythromycin, these eight children showed a significant difference between pre-prandial and post-prandial dominant power (46.00 dB vs 49.69 dB, p=0.017). None developed drug-related complication. Conclusions: EGG can demonstrate abnormal gastric myoelectrical activity in children having dyspeptic symptoms. Short-term erythromycin significantly improves the symptoms and EGG patterns of these patients.

目的:紅黴素是一種促動劑,能提高胃平滑肌的收縮力。在這項研究中,我們調查短期口服紅黴素對兒童消化不良症狀的影響。方法:共8名7-18歲患有持續性消化不良症狀的兒童。他們的消化不良症狀評分和胃電圖(EGG)模式都出現異常。所有的兒童均給予紅黴素懸浮液2mg/kg體重劑量,每天三次,連續2周。結果:8名兒童完成了 2周的紅黴素療程。治療前後,平均消化不良症狀評分,分別為6.75和4.63(p=0.025)。治療前後,平均EGG 胃電節律時間分別為65.87%和77.58%(p=0.012)。紅黴素療程後,這8名孩子在餐前和餐後的主功率(46.00分貝與49.69分貝,p=0.017)之間出現顯著的差異。沒有與藥物相關的併發症。結論:兒童消化不良症狀的EGG可顯示胃電活動異常。短期紅黴素能明顯改善這情況。

Keyword : Children; Dyspepsia; Electrogastrography; Erythromycin



This web site is sponsored by Johnson & Johnson (HK) Ltd.
©2022 Hong Kong Journal of Paediatrics. All rights reserved. Developed and maintained by Medcom Ltd.