Table of Contents

HK J Paediatr (New Series)
Vol 17. No. 2, 2012

HK J Paediatr (New Series) 2012;17:115-118

Original Article

Association of Benign Joint Hypermobility Syndrome with Mitral Valve Prolapse in Iranian Children

R Shiari, F Vaziri, H Javaherizadeh, E Zahmatkesh, M Torabizadeh, M Zadkarami, H Nezhad-Biglari


Aim and purpose: The aim of this study was to determine the association of benign joint hypermobility syndrome (BJHS) with mitral valve prolapse. Subjects and methods: This is a case-control study. Sixty-three children with benign joint hypermobility syndrome were included in case group and 63 without any rheumatologic disease were placed in control group. We used Carter-Wilkinson and Beighton criteria for diagnosing of benign joint hypermobility syndrome. Mitral valve prolapse was evaluated by echocardiography in both groups. The mitral leaflet displacement >2 mm considered as cut off for diagnosis of mitral valve prolapse. Cardiologist did not have any information about patients group during echocardiography. Data was analysed using SPSS ver. 13.0. Chi-square used for comparison. Results: In this study, 32 girls and 31 boys were included. Mean of age in case group was 7.1±2.67 and for control was 6.9±3.25 years. Mitral valve prolapse was discovered in 54% of cases and 12.7% of control groups (P=0.001). Mitral valve prolapse was significantly higher among cases with BJHS aged >7 (58.8%) year compared to 3-7 (41.2%) year of age (P=0.027). Heart murmur and palpitation was more common among children with benign joint hypermobility syndrome with mitral valve prolapse compared to children without mitral valve prolapse (P<0.05). Conclusion: The incidence of mitral valve prolapse among children with benign joint hypermobility was significantly higher than control group.

目的:本文目的是研究良性關節過動症候群(BJHS)與二尖瓣脫垂的關係。研究方法:採用病例-對照研究方法。病例組63名良性關節過動症候群兒童,63名無任何風濕性疾病的兒童被安排進入對照組。根據Carter-Wilkinson 及Beighton 標準診斷良性關節過動症候群。根據超聲心動檢查判斷二尖瓣脫垂,以二尖瓣小葉移位大於2 mm作為診斷二尖瓣脫垂的標準。進行超聲心動檢查的醫生未被告知任何病人分組的情況。最後採用SPSS 13.0 卡方檢驗進行資料的分析比較。結果:本組研究包括32名女童和31名男童。平均年齡病例組7.1±2.67歲,對照組6.9±3.25歲。病例組54%病人伴有二尖瓣脫垂,對照組為12.7%(P=0.001)。病例組中7歲以上病人58.8%有二尖瓣脫垂,年齡於3-7歲間的病人41.2%有二尖瓣脫垂(P=0.027)。心臟雜音與心悸更多見於BJHS 伴二尖瓣脫垂病人(P<0.05)。結論:良性多動關節症候群病人組二尖瓣脫垂的發生率顯著高於對照組。

Keyword : Beighton criteria; Benign joint hypermobility syndrome; Mitral valve prolapse; Rheumatologic disease



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