YQ Teng, JX Yao, W Zhu, X Yan, QY Lu, J Jin

Abstract

Objectives: To analyse the clinical manifestations of neonates suffering from cow's milk allergy (CMA), and to explore the treatment of CMA in neonates, as well as to conduct a one-year follow-up study. Study design: To conduct a clinical chart review of a small cohort of neonates of confirmed cow's milk allergy. Results: Eleven neonates were diagnosed as suffering from CMA from May 2008 to May 2010, all of which also had digestive tract symptoms. Five were suffering from eczema at the same time. Five had positive sIgE. The other six got negative sIgE and diagnosed as having CMA when using milk to conduct food-avoiding challenge test. In the following one year, nine got tolerance to milk. Conclusions: The clinical manifestations of neonates suffering from CMA were diversified; the positive rate of sIgE is not high; food-elimination challenge test could be an alternative for diagnosing food allergy. Significant outcome can be achieved when applying food-avoiding treatments to milk-fed infants. Within one year, 9/11 (82%) of the infants suffering from CMA got tolerance to cow's milk.

目的：分析新生兒牛奶過敏的臨床表現，初步探索新生兒牛奶過敏的診斷和治療，並對預後進行隨訪1年。方法：通過測定過敏原特异性IgE及食物回避─激發試驗診斷牛奶過敏。結果：2008年5月-2010年5月期間發現新生兒牛奶過敏11例，所有病例均有消化道症狀，5例同時伴皮膚症狀（eczema）。11例中，發現牛奶sIgE陽性5例，牛奶sIgE陰性、用牛奶作激發試驗診斷牛奶過敏6例。隨訪1年，9例出現牛奶耐受。結論： 新生兒牛奶過敏臨床表現多樣，sIgE檢測陽性率不高；食物回避-激發試驗可作為食物過敏的補充診斷手段；對奶粉喂養兒，食物回避療法可取得明顯療效；在1年內，9/11（82%）的患兒產生食物耐受。