YQ Teng, JX Yao, W Zhu, X Yan, QY Lu, J Jin

Abstract

Objectives: To analyse the clinical manifestations of neonates suffering from cow's milk allergy (CMA), and to explore the treatment of CMA in neonates, as well as to conduct a one-year follow-up study. Study design: To conduct a clinical chart review of a small cohort of neonates of confirmed cow's milk allergy. Results: Eleven neonates were diagnosed as suffering from CMA from May 2008 to May 2010, all of which also had digestive tract symptoms. Five were suffering from eczema at the same time. Five had positive sIgE. The other six got negative sIgE and diagnosed as having CMA when using milk to conduct food-avoiding challenge test. In the following one year, nine got tolerance to milk. Conclusions: The clinical manifestations of neonates suffering from CMA were diversified; the positive rate of sIgE is not high; food-elimination challenge test could be an alternative for diagnosing food allergy. Significant outcome can be achieved when applying food-avoiding treatments to milk-fed infants. Within one year, 9/11 (82%) of the infants suffering from CMA got tolerance to cow's milk.