Department of Paediatrics, Huazhong Technology and Science University, Tongji Medical College, Tongji Hospital, Wuhan, China
H Xiong (熊昊) MD Candidate
Q Hu (胡群) MD
Department of Paediatrics and Adolescent Medicine, The University of Hong Kong, Li Ka Shing Faculty of Medicine, Queen Mary Hospital, 102 Pokfulam Road, Pokfulam, Hong Kong, China
SY Ha (夏修賢) FRCP, FHKAM
AKS Chiang (蔣國誠) MBChB, PhD, FHKAM
YL Lau (劉宇隆) MD, FHKAM
GCF Chan (陳志峰) MD, FHKAM
Correspondence to: Prof GCF Chan
Received July 14, 2010
Leukoencephalopathy is a severe but often reversible neurological complication with high dose intravenous methotrexate (MTX). It is much rarer after intrathecal MTX. We report a 13-year-old girl suffered from leukoencephalopathy 7 days after intrathecal MTX administration. The sequential MRI changes are highlighted in this report. Rescue therapy with aminophylline and high-dose folinic acid was given for 10 days. Her neurological status in terms of the speech and motor function gradually improved afterwards.
