Table of Contents

HK J Paediatr (New Series)
Vol 15. No. 4, 2010

HK J Paediatr (New Series) 2010;15:327-331

Case Report

Reversible Leukoencephalopathy Following Intrathecal Methotrexate

H Xiong, SY Ha, AKS Chiang, YL Lau, Q Hu, GCF Chan


Leukoencephalopathy is a severe but often reversible neurological complication with high dose intravenous methotrexate (MTX). It is much rarer after intrathecal MTX. We report a 13-year-old girl suffered from leukoencephalopathy 7 days after intrathecal MTX administration. The sequential MRI changes are highlighted in this report. Rescue therapy with aminophylline and high-dose folinic acid was given for 10 days. Her neurological status in terms of the speech and motor function gradually improved afterwards.

Keyword : Intrathecal; Leukoencephalopathy; Magnetic resonance imaging; Methotrexate

Abstract in Chinese


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