Table of Contents

HK J Paediatr (New Series)
Vol 15. No. 3, 2010

HK J Paediatr (New Series) 2010;15:214-223

Invited Article

Diabetes Angiopathy in Children

F Chiarelli, D Di Marzio


Objective: To review currently available evidence on the molecular mechanisms, risk factors and outcomes of mico- and macrovascular complications in children with type 1 diabetes mellitus. Data sources and study selection: Medline, Pubmed, and Cochrane Library searches of internationally published English language journals, from 1985 to February 2010 using the terms "diabetes", "children", "complications", "angiopathy" and "management". Data extraction: All articles involving diabetes vascular complications in children were included in the review. Data synthesis: During the natural history of diabetes several molecular, receptorial and cellular factors provide a continuous mechanism of vascular damage. In children with diabetes this state is present at an early age so that accelerated atherosclerosis is associated with an increased risk of micro- and macrovascular complications as compared to the non-diabetic paediatric population. The major long term complications of diabetes can be divided into micro- (nephropathy, retinopathy and neuropathy) and macrovascular complications. Childhood remains a period during which intensive education and treatment may prevent or delay the onset and progression of these complications. Conclusions: Although the prognosis has improved considerably in recent years due to the advances in the therapeutic interventions, systematic regular screening continues to have a pivotal role in the management of complications in diabetic children. Primary prevention to all risk factors for vascular complications is essential and intervention is indicated if necessary even in childhood.

Keyword : Angiopathy; Children; Oxidative stress; Type 1 diabetes

Abstract in Chinese


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