Table of Contents

HK J Paediatr (New Series)
Vol 14. No. 4, 2009

HK J Paediatr (New Series) 2009;14:282-290

Case Report

A Case of Early Neonatal Fulminant Liver Failure and Haemophagocytic Lymphohistiocytosis
一例早發性新生兒爆發性肝衰竭及噬血細胞淋巴組織細胞增生症

STH Fung, TF Tong, mpy Chow


Abstract

Both liver failure and haemophagocytic lymphohistiocytosis are rare conditions during the neonatal period. We report a case of fulminant neonatal liver failure that presented on the first day of life and was subsequently diagnosed to have haemophagocytic lymphohistiocytosis (HLH). Work up for secondary causes was not revealing and our patient might represent a case of familial HLH although the more definitive genetic testing was not performed. To our knowledge, this is the youngest reported case of HLH in this locality. HLH should be considered in cases of perinatal liver failure.

肝衰竭和噬血細胞淋巴組織細胞增生症都是新生兒期罕見的疾病。我們報導了一例患者出生後當天就患爆發性新生兒肝衰竭,隨之被診斷患有噬血細胞淋巴組織細胞增生症。檢查未發現繼發性病因,雖然未進行確定性的遺傳學檢查,患者可能屬家族性噬血細胞淋巴組織細胞增生症。就我們所知,這是本地所報導年齡最小的患者。圍產期肝衰竭應該考慮到噬血細胞淋巴組織細胞增生症的可能性。

Keyword : Acute liver failure; Haemophagocytic lymphohistiocytosis; Neonates

關鍵詞:急性肝衰竭、噬血細胞淋巴組織細胞增生症、新生兒

 
 

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