The Epidemic of Type 2 Diabetes Mellitus in Adolescents
The worldwide prevalence of type 2 diabetes is expected to increase in the next two decades and the adult diabetic population in China is projected to reach 46 million by 2025.1 Type 2 diabetes mellitus has conventionally been described as a chronic disease of overweight middle-aged adults and the elderly but there is now evidence that this disease in also becoming more prevalent in children and adolescents of developed and developing countries.1-5 The article by Huen et al6 in this issue is a timely reminder that Hong Kong has not been spared from this epidemic. This emerging epidemic of type 2 diabetes mellitus can have significant financial and societal consequences and a prompt public health response is warranted.
One of the recommendations of the International Diabetes Federation Consensus Workshop on type 2 diabetes in the young is that population-based incidence/prevalence of type 2 diabetes mellitus in different countries should be collected followed by studies on the natural history and outcome of the disease. Certain ethnic groups including Hispanics, African-Americans, Canadian First Nations People, Native Americans and Asians have been reported to be at high risk of developing type 2 diabetes in adolescence and adulthood.1
Since 1974, urine has been collected from primary and junior high school children in Japan to be tested for glucose to detect diabetes. About 0.05-0.1% of primary school children and 0.12-0.2% of junior high school children have tested positive for urine glucose and 0.05% of the children have glycosuria on retesting. The incidence of type 2 diabetes has been estimated to be 3.0/100,000 children during 1975-2000.3 The rising incidence of childhood type 2 diabetes has been attributed to a concomitant increase in childhood obesity associated with a Westernized and sedentary life style in Japan.3 Over 80% of identified cases were overweight or obese and obesity was more common in boys than in girls (91.5% versus 77%). However, a recent trend towards a decrease in the incidence of childhood type 2 diabetes in the Tokyo area had been reported.7
A nationwide urine screening programme for diabetes among 2,862,083 school children was carried out in Taiwan between 1992-1999 and the estimated rate for type 2 diabetes was 6.5 per 100,000.8 Only 54% of boys and 44% of girls with type 2 diabetes type 2 diabetes were obese in this cohort.8 Since these landmark studies, many population-based incidence of childhood type 2 diabetes mellitus from different countries have been published (Table 1) with the incidence remaining fairly low in European countries as compared to America and the Pacific Islands. Among clinic based reports, the percentage of type 2 diabetes mellitus among newly diagnosed diabetic children and adolescents is also on the increase (Table 2). Between 1984 and 1996, only 7.3% of newly diagnosed diabetes cases in Hong Kong were type 2 diabetes but between 1997 to 2007, 47% of newly diagnosed diabetic patients had type 2 diabetes. This dramatic increase in type 2 diabetes in Hong Kong is paralleled by an increase in the prevalence of obesity in Hong Kong in the past two decades (Table 3).33
The clinical presentation of childhood and adolescent type 2 diabetes can vary from minimal symptomatology to severe hyperglycaemia and ketoacidosis (5-25%). The differentiation of type 2 diabetes from type 1 diabetes in adolescence can be difficult. Based on the Taiwan experience, nearly 40% of Chinese type 2 diabetic patients are not obese. Acanthosis nigricans, polycystic ovary syndrome, non-alcoholic liver disease, hypertension and hyperlipidaemia are commonly associated features of type 2 diabetes and 74-100% of the patient have first or second-degree relatives with type 2 diabetes.1,34,35 Between 10% to 75% of Caucasian youths diagnosed clinically with type 2 diabetes have islet cell antibodies (ICAs), insulin autoantibodies (IAA), glutamic acid decarboxylase (GAD) and tyrosine phosphatase antibodies (IA2)34 but such information is not available in Chinese patients. The majority of type 2 diabetic patients diagnosed in our centre are islet-cell antibody negative, but we have to bear in mind that more than half of the type 1 diabetes in Chinese youths are idiopathic in nature. It has been reported that antibody-negative type 2 diabetic Caucasian youths are more insulin resistant whereas antibody-positive patients have insulin deficiency and b-cell failure. Phenotypically, there is no difference between antibody-positive versus antibody-negative type 2 diabetic patients with regard to HbA1c and glucose values, symptomatic presentation, family history of diabetes, body mass index and age of presentation.34
As mentioned in the article by Huen et al,6 screening for diabetes by testing urine glucose in obese Hong Kong adolescents over 10 years of age was initiated by the School Health Service of the Department of Health in 2004. In the 2004 /2005 school year, 4.99% of over 300,000 adolescents attending the School Health Service were obese and glycosuria was detected in 0.018% of this cohort with a confirmed prevalence of type 2 diabetes mellitus of 5.8 per 100,000 children and impaired glucose tolerance in 1.6 per 100,000 children over 10 years of age (Dr KH Mak, School Health Service, personal communication). However, children and adolescents with type 2 diabetes who are not obese will not be detected by this programme. The sensitivity of glycosuria in the screening for diabetes is low. Although the cost of urine test is low, it was estimated that the cost for identifying a youth with glycosuria was US$4028 to US$10,000.1,8
The American Diabetes Association recommends screening for diabetes in obese adolescents (BMI >85th percentile) and presence of family history of type 2 diabetes and signs of insulin resistance (acanthosis nigricans, dyslipidaemia, hypertension and polycystic ovary syndrome) by performing a fasting blood glucose every two years.35 Impaired fasting glucose is defined as a fasting glucose 5.7-6.9% mmol/L. Fasting blood sugar is highly correlated with repeated measurements but the reproducibility of oral glucose tolerance test is poor36 and HbA1c determination is not significantly sensitive. The blood sugar two hours after glucose challenge has been suggested to be more sensitive for the diagnosis of diabetes and impaired glucose tolerance.37 In a cohort of 180 obese Chinese adolescents (mean age 10.5?.4 years and BMI of 28.6?.7 kg/m2), asymptomatic diabetes was found in 2.7% and impaired glucose tolerance was found in 15.5% of patients (by oral glucose tolerance test).38 As the prevalence of type 2 diabetes in youth remains relatively low, it may not be cost-effective to perform universal screening. Even for targeted screening adopted in Hong Kong, it remains to be proven that screening and early detection of type 2 diabetes in adolescents will improve outcome. Follow-up studies and some form of cost analysis is required to assess the urine glucose screening programme in Hong Kong school children.
1. Alberti G, Zimmet P, Shaw J, Bloomgarden Z, Kaufman F, Silink M. Type 2 diabetes in the young: the evolving epidemic: the international diabetes federation consensus workshop. Diabetes Care 2004;27:1798-811.
2. Kiess W, Böttner A, Raile K, et al. Type 2 diabetes mellitus in children and adolescents: a review from a European perspective. Horm Res 2003;59 Suppl 1:77-84.
3. Urakami T, Morimoto S, Nitadori Y, Harada K, Owada M, Kitagawa T. Urine glucose screening program at schools in Japan to detect children with diabetes and its outcome-incidence and clinical characteristics of childhood type 2 diabetes in Japan. Pediatr Res 2007;61:141-5.
4. Ramachandran A, Snehalatha C, Satyavani K, Sivasankari S, Vijay V. Type 2 diabetes in Asian-Indian urban children. Diabetes Care 2003;26:1022-5.
5. Unnikrishnan AG, Bhatia E, Bhatia V, et al. Type 1 diabetes versus type 2 diabetes with onset in persons younger than 20 years of age. Ann N Y Acad Sci 2008;1150:239-44.
6. Huen KF, Low LC, Cheung PT, et al. An update on the epidemiology of childhood diabetes in Hong Kong. HK J Paediatr (new series) 2009;14:252-9.
7. Urakami T, Owada M, Kitagawa T. Recent trend toward decrease in the incidence of childhood type 2 diabetes in Tokyo. Diabetes Care 2006;29:2176-7.
8. Wei JN, Sung FC, Lin CC, Lin RS, Chiang CC, Chuang LM. National surveillance for type 2 diabetes mellitus in Taiwanese children. JAMA 2003;290:1345-50.
9. Haines L, Wan KC, Lynn R, Barrett TG, Shield JP. Rising incidence of type 2 diabetes in children in the U.K. Diabetes Care 2007;30:1097-101.
10. Thunander M, Petersson C, Jonzon K, et al. Incidence of type 1 and type 2 diabetes in adults and children in Kronoberg, Sweden. Diabetes Res Clin Pract 2008;82:247-55.
11. Lammi N, Taskinen O, Moltchanova E, et al. A high incidence of type 1 diabetes and an alarming increase in the incidence of type 2 diabetes among young adults in Finland between 1992 and 1996. Diabetologia 2007;50:1393-400.
12. Schober E, Waldhoer T, Rami B, Hofer S; Austrian Diabetes Incidence Study Group. Incidence and time trend of type 1 and type 2 diabetes in Austrian children 1999-2007. J Pediatr 2009;155:190-3 e1.
13. Craig ME, Femia G, Broyda V, Lloyd M, Howard NJ. Type 2 diabetes in indigenous and non-indigenous children and adolescents in New South Wales. Med J Aust 2007;186:497-9.
14. Campbell-Stokes PL, Taylor BJ. Prospective incidence study of diabetes mellitus in New Zealand children aged 0 to 14 years. Diabetologia 2005;48:643-8.
15. Pinhas-Hamiel O, Zeitler P. The global spread of type 2 diabetes mellitus in children and adolescents. J Pediatr 2005;146:693-700.
16. Bell RA, Mayer-Davis EJ, Beyer JW, et al. Diabetes in non-Hispanic white youth: prevalence, incidence, and clinical characteristics: the SEARCH for Diabetes in Youth Study. Diabetes Care 2009;32 Suppl 2:S102-11.
17. Liu LL, Yi JP, Beyer J, et al. Type 1 and Type 2 diabetes in Asian and Pacific Islander U.S. youth: the SEARCH for Diabetes in Youth Study. Diabetes Care 2009;32 Suppl 2:S133-40.
18. Mayer-Davis EJ, Beyer J, Bell RA, et al. Diabetes in African American youth: prevalence, incidence, and clinical characteristics: the SEARCH for Diabetes in Youth Study. Diabetes Care 2009;32 Suppl 2:S112-22.
19. Dabelea D, DeGroat J, Sorrelman C, et al. Diabetes in Navajo youth: prevalence, incidence, and clinical characteristics: the SEARCH for Diabetes in Youth Study. Diabetes Care 2009;32 Suppl 2:S141-7.
20. Lawrence JM, Mayer-Davis EJ, Reynolds K, et al. Diabetes in Hispanic American youth: prevalence, incidence, demographics, and clinical characteristics: the SEARCH for Diabetes in Youth Study. Diabetes Care 2009;32 Suppl 2:S123-32.
21. Huen KF, Low LC, Wong GW, et al. Epidemiology of diabetes mellitus in children in Hong Kong: the Hong Kong childhood diabetes register. J Pediatr Endocrinol Metab 2000;13:297-302.
22. Czernichow P, Tubiana-Rufi N. Emergence of type 2 diabetes in French children. Bull Acad Natl Med 2004;188:1443-51.
23. Zhi D, Shen SS, Luo FH, Zhao Z, Hong Q. IDFWPR childhood and adolescence Diabcare Survey 2001 in Shanghai (Abstract) 0-25 ISPAD Saint - Malo 2003.
24. Hotu S, Carter B, Watson PD, Cutfield WS, Cundy T. Increasing prevalence of type 2 diabetes in adolescents. J Paediatr Child Health 2004;40:201-4.
25. Zachrisson I, Tibell C, Bang P, Ortqvist E. Prevalence of type 2 diabetes among known cases of diabetes age 0-18 in Sweden (Abstract). 18th International Diabetes Federation Congress 2003, Paris, France.
26. Likitmaskul S, Kiattisathavee P, Chaichanwatanakul K, Punnakanta L, Angsusingha K, Tuchinda C. Increasing prevalence of type 2 diabetes mellitus in Thai children and adolescents associated with increasing prevalence of obesity. J Pediatr Endocrinol Metab 2003;16:71-7.
27. Zdravkovic V, Daneman D, Hamilton J. Presentation and course of Type 2 diabetes in youth in a large multi-ethnic city. Diabet Med 2004;21:1144-8.
28. Rami B, Schober E, Nachbauer E, Waldhör T; Austrian Diabetes Incidence Study Group. Type 2 diabetes mellitus is rare but not absent in children under 15 years of age in Austria. Eur J Pediatr 2003;162:850-2.
29. Punnose J, Agarwal MM, El Khadir A, Devadas K, Mugamer IT. Childhood and adolescent diabetes mellitus in Arabs residing in the United Arab Emirates. Diabetes Res Clin Pract 2002;55:29-33.
30. Moore KR, Harwell TS, McDowall JM, Helgerson SD, Gohdes D. Three-year prevalence and incidence of diabetes among American Indian youth in Montana and Wyoming, 1999 to 2001. J Pediatr 2003;143:368-71.
31. Grinstein G, Muzumdar R, Aponte L, Vuguin P, Saenger P, DiMartino-Nardi J. Presentation and 5-year follow-up of type 2 diabetes mellitus in African-American and Caribbean-Hispanic adolescents. Horm Res 2003;60:121-6.
32. Pinhas-Hamiel O, Dolan LM, Daniels SR, Standiford D, Khoury PR, Zeitler P. Increased incidence of non-insulin-dependent diabetes mellitus among adolescents. J Pediatr 1996;128:608-15.
33. So HK, Nelson EA, Li AM, et al. Secular changes in height, weight and body mass index in Hong Kong Children. BMC Public Health 2008;8:320.
34. Tfayli H, Bacha F, Gungor N, Arslanian S. Phenotypic type 2 diabetes in obese youth: insulin sensitivity and secretion in islet cell antibody-negative versus -positive patients. Diabetes 2009;58:738-44.
35. American Diabetes Association. Type 2 diabetes in chidlren and adolescents. Diabetes Care 2000;23:381-9.
36. Libman IM, Barinas-Mitchell E, Bartucci A, Robertson R, Arslanian S. Reproducibility of the oral glucose tolerance test in overweight children. J Clin Endocrinol Metab 2008;93:4231-7.
37. Sinha R, Fisch G, Teague B, et al. Prevalence of impaired glucose tolerance among children and adolescents with marked obesity. N Engl J Med 2002;346:802-10.
38. Au RWM. Childhood obesity in Hong Kong: medical and psychological sequelae. Thesis submitted to the University of Hong Kong in partial fullfillment of the requirements for the Degree of Master of Medical Science, December 2003.
This web site is sponsored by Johnson & Johnson (HK) Ltd.