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HK J Paediatr (New Series)
Vol 14. No. 2,
2009
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HK J Paediatr (New Series) 2009;14:103-107
Original Article
Long Versus Standard Course Corticosteroid Therapy for Nephrotic Syndrome in Children
ALT Ma, ETL Soo, PC Tong, WM Lai, KC Tse, MC Chiu Paediatric Nephrology Centre, Department of Paediatrics and Adolescent Medicine, Princess Margaret Hospital,
Lai Chi Kok, Kowloon, Hong Kong SAR ALT Ma (馬立德) MBBS (HK), DCH(HK), MRCPCH
ETL Soo (蘇頌良) MBBS (HK), DCH(HK)
PC Tong (湯伯朝) MBBS(HK), MRCP, FHKPaed
WM Lai (賴偉明) MBBS(HK), FHKAM (Paed), FRCPaed
KC Tse (謝紀超) MBBS(HK), FHKCPaed(HK), FRCP(Edin)
MC Chiu (趙孟準) MBBS(HK), FHKAM (Paed), FRCPCH Correspondence to: Dr ALT Ma Received January 12, 2009
Abstract Steroid sensitive nephrotic syndrome (SSNS) is a common disease in childhood. Although most children respond to corticosteroid, relapse is a common problem. We aim to compare the effect of 2-month steroid treatment (standard course) according to International Study of Kidney Disease of Children (ISKDC) versus 6-month treatment (long course) on the clinical course of SSNS in a 1.5-year follow up in our centre. Medical records of patients seen from 1997-2006 were reviewed. A total of 46 patients were included in the study (standard course group=22, long course group=24). Patients treated with long course steroid had significantly lower relapse rate (33% versus 75%, p= 0.026) and higher percentage of sustained remission (p=0.0046) than that of standard course. None of our patients had significant growth retardation or hypertension. Therefore, 6-month corticosteroid may be preferable to the standard course for the initial treatment of SSNS in children. Keyword : Corticosteroids; Relapses; Steroid sensitive nephrotic syndrome
Abstract in Chinese
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