Table of Contents

HK J Paediatr (New Series)
Vol 14. No. 2, 2009

HK J Paediatr (New Series) 2009;14:103-107

Original Article

Long Versus Standard Course Corticosteroid Therapy for Nephrotic Syndrome in Children

ALT Ma, ETL Soo, PC Tong, WM Lai, KC Tse, MC Chiu


Steroid sensitive nephrotic syndrome (SSNS) is a common disease in childhood. Although most children respond to corticosteroid, relapse is a common problem. We aim to compare the effect of 2-month steroid treatment (standard course) according to International Study of Kidney Disease of Children (ISKDC) versus 6-month treatment (long course) on the clinical course of SSNS in a 1.5-year follow up in our centre. Medical records of patients seen from 1997-2006 were reviewed. A total of 46 patients were included in the study (standard course group=22, long course group=24). Patients treated with long course steroid had significantly lower relapse rate (33% versus 75%, p= 0.026) and higher percentage of sustained remission (p=0.0046) than that of standard course. None of our patients had significant growth retardation or hypertension. Therefore, 6-month corticosteroid may be preferable to the standard course for the initial treatment of SSNS in children.

Keyword : Corticosteroids; Relapses; Steroid sensitive nephrotic syndrome

Abstract in Chinese


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