Table of Contents

HK J Paediatr (New Series)
Vol 12. No. 4, 2007

HK J Paediatr (New Series) 2007;12:270-282

Review Article

Recent Advances in Childhood Atopic Dermatitis
關於兒童異位性皮炎的新進展

CK Yeung, HHL Chan


Abstract

Significant progress has been made in the understanding of the pathogenesis of atopic dermatitis but the cure remains elusive. The management strategy is therefore to reduce the disease exacerbation and produce comfort for affected children and their families. Thorough clinical assessment helps to guide the education process which is an essential part of management. Use of topical corticosteroids and emollients remain the first line management together with avoidance of triggers. The topical immunomodulating agents, tacrolimus and pimecrolimus have broadened the armamentarium in the management of atopic dermatitis. Use of systemic immunosuppressants is now proved to be safe and effective for refractory atopic dermatitis provided that proper ways of monitoring side effects are adopted. Novel management approach, such as probiotics, has evolved from advances in our understanding of the pathobiology of this common skin disease.

雖然醫學上對於異位性皮炎的發病機制有著顯著的突破,但其療效依然是不太肯定的。治療的對策因此變成以對症為主,主要以減輕病變的惡化和舒緩症狀。徹底的臨床評估對於指導治療十分重要。局部外用激素及軟化劑、避免刺激依然是第一線治療。局部外用免疫調節劑如他克美司、吡美莫司等、使治療多一選擇。對於難治性異位性皮炎,全身性免疫抑制劑被証實是有效及安全的,但應用的前提是要監測副作用。對於治療這常見病,一些嶄新的療法、如前生物學,是稍為超出了我們的理解範圍。

Keyword : Atopic dermatitis; Children; Eczema; Management review

關鍵詞:異位性皮炎、兒童、濕疹、治療回顧

 
 

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