Table of Contents

HK J Paediatr (New Series)
Vol 12. No. 2, 2007

HK J Paediatr (New Series) 2007;12:111-117

Occasional Survey

Endotoxin-Induced Circulatory Changes in the Newborn Brain: A Review

SYS Feng, VYH Yu, AM Walker


Endotoxin induces complex changes in the newborn cerebral circulation, including vasoconstriction by down-regulating endothelial nitric oxide synthase and stimulating the production of endothelin and cyclooxygenase-2 derived vasoconstrictors including thromboxane A2, while also promoting vasodilatation by increasing the expression of inducible nitric oxide synthase and cyclooxygenase-2 derived vasodilators. Together, these changes represent a complex dysregulation of the newborn cerebral circulation. This review considers the effects of neonatal endotoxaemia on cerebral circulatory changes and endothelium-derived factors, and their implications for cerebral circulatory control.

Keyword : Cerebral blood flow; Endothelium; Endotoxin; Newborn

Abstract in Chinese


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