J Neu

Abstract

Epidemiologic studies show a strong relationship between early nutrition and growth and subsequent metabolic problems such as obesity, type 2 diabetes, hypertension and atherosclerosis (the metabolic syndrome). Genetic predispositions and high food intake play significant roles, but epigenetic mechanisms are also likely to be involved. Largely based on studies from animals, we are just beginning to understand the mechanisms of these developmental origins of disease in adulthood. Here we briefly discuss these mechanism and provide suggestions for a rational approach to early nutrition.