Table of Contents

HK J Paediatr (New Series)
Vol 1. No. 1, 1996

HK J Paediatr (New Series) 1996;1:44-47

Original Article

Acute Myeloid Leukaemia: Treatment and Outcome

CK Li, MK Shing, KW Chik, DH Lai, TK Lam, MP Yuen


Patients diagnosed to have acute myeloid leukaemia in Prince of Wales Hospital were retrospectively analyzed. From 1984 to 1995, a total of 36 newly diagnosed cases were included in the study. The mean age of diagnosis was 6.5 years. Acute myelomonocytic and megakaryocytic leukaemias were the commonest subtypes. Hyperleucocytosis occurred in 28.2% of patients. Fifteen patients were treated with less intensive treatment in the earlier years (Group A). Twenty patients were treated with a more intensive treatment in the more recent years (Group B). Group A patients had lower remission rate as compared with Group B (66.6% Vs 84.2%). Early deaths and non-leukaemia deaths during remission occurred in ten patients (27.6%). Five patients received bone marrow transplantation two unrelated allogeneic and three autologous BMT. The 5 years disease free survival of Group A and Group B patients were 32.0 % and 57.2% respectively. Intensive chemotherapy improved the cure rate in acute myeloid leukaemia patients.

Keyword : Acute myeloid leukaemia; Bone marrow transplant; Chemotherapy; Disease free survival

Abstract in Chinese


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