Table of Contents

HK J Paediatr (New Series)
Vol 2. No. 2, 1997

HK J Paediatr (New Series) 1997;2:129-133

Original Article

Maturation of Reproductive Functions in Chinese Adolescents
中國青少年生殖功能的成熟

DF Wang, FS Chen, HF Liu, PX Chen, WQ Oian, KQ Lu, MF Fu, YF Chui, W Wang, JS Zheng


Abstract

A group of Chinese school boys aged 10-16 years old were investigated for their emission of spermatozoa in urine "spermaturia" and the urinary excretion of testosterone (T) levels. Nuclear areas and relative DNA contents of spermatozoa in urine were also measured. Results showed that the median age of onset of spermaturia was 13.7 years. Frequency of spermaturia increased with ages between 11-16 years; it also increased with pubertal stages between Tanner stages 3 to 5 (G3-G5). 67% of the boys studied showed spermaturia in 6 consecutive days of their urine samples; 10% of those in pubertal stages G4 and G5 showed spermaturia 3 to 5 times in 6 days. Levels of urinary T from positive samples were higher than that from the negative ones. Also urinary T was higher in patients in whom spermaturia revealed more than once during the study period. Another group of the teenage school girls (10-15 years old) in our longitudinal survey showed that the menarcheal age was 12.51±0.97 years. Ovulatory cycles of post menarcheal girls were studied by serial urinary progesterone (P) levels determined between two menstrual cycles and covering both the luteal (L) and the follicular (F) phases. Urinary P levels were corrected by creatinine (Cr) concentration. By using the ratio of PL/Cr to PF/Cr > 2 as a criteria for identification of ovulatory cycles according to the data in adult women controls, we found the rates of ovulatory cycles to be 8.1, 11.9, 35.7 and 46.2 % for girls with gynecologic age of 0.5, 1.0, 2.0 and 2.5 years respectively. Ovulation might start as early as gynecologic age of 0.04-0.3 years during the 2nd or the 4th post-menarcheal cycle. We concluded that the non invasive method utilizing multiple urine samples, for assays of spermaturia and hormonal (T,P) measurements could be effectively used in the study of maturation of adolescent reproductive functions.

我們對一組10-16歲中國在校男性青少年尿液中精子(精液尿症)和睪酮(T)水平進行了研究,同時測定了這些精子的核區及相關的DNA含量。結果顯示“精液尿症”的初發年齡中位數是13.7歲,從11歲到16歲,“精液尿症”的頻率隨著年齡而增加。在Tanner分期3到5期(G3-G5),該頻率亦隨著青春期分期的增加而增加。有67%男孩的尿液在連續的6天檢查中均顯示有“精液尿症”;其中有10%處於G4和G5期的男孩在6天中顯示“精液尿症”3至5次。陽性樣本中尿睪酮水平高於陰性樣本。在研究期間“精液尿症”多於1次的男孩其尿中睪酮含量亦較高。另一組對在校女性青少年(10-15)歲的縱向調查顯示月經初潮為12.5±0.97歲。我們亦對月經初潮後女孩的排卵期進行了研究。方法是連續地測定包括黃體期(L)和卵泡期(F)在內的兩次月經周期之間的尿黃體酮(P)水平。尿黃體酮水平並用肌酐(Cr)濃度糾正。根據在成年婦女對照組的數據,PL/ Cr比PF/Cr大於2被用作認定有排卵期指標。我們發現在婦科學年齡為0.5,1.0,2.0和2.5歲的女孩,其出現排卵周期的百分率分別為8.1,11.9,35.7和46.2%。排卵可早在婦科年齡0.04-0.3歲於月經初潮後第2-4周期內發生。我們認為非創傷性多次分析尿樣本中“精液尿症”和激素(T、P)水平,可以作為一種有效的方法供研究青少年生殖功能的成熟。

Keyword : Adolescent; Ovulatory cycle; Spermaturia

 
 

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