Proceedings of The First Current Topic in Infectious Diseases
Overview and Disease Burden of Streptococcus Pneumoniae in China
There were limited data about Streptococcus pneumoniae infections in China. The first study on the epidemiology of S. pneumoniae was performed in collaboration with World Health Organization during 1982-1985. It included 27 hospitals from 18 provinces, with more than 400 cases of pneumococcal infections. The rates of pneumococcal pneumonia, meninigitis and otits media were 14 cases, 79 cases and 68 cases per 1000 homologous disease cases respectively. Most of the cases were in children less than or equal to three years old. The mortality rates for pneumococcal pneumonia and meningitis were 16.4% and 16% respectively. Majority of them were patients less than 1 year old or more than 50 years old. Overall, the six commonest serotypes found in this study, in descending order, were 5, 6, 1, 19, 2 and 14. They accounted for 59% of all S. pneumoniae identified in the study. In descending order of frequency, the "pneumonia-related" serotypes were 1, 5, 14, 6, 21 and 28 while the "meningitis-related" serotypes were serotypes 2, 5, 6, 1, 27 and 14. Compared to overseas data, the incidence of type 5 pneumococcal infections in China was higher. Another study on acute bacterial meningitis in children was conducted in Hefei from 1990 to 1992. Of all the bacterial meningitis in children between the age of one month to five years old, 8.3% were caused by S. pneumoniae. The case fatality rate was up to 20%. Nonetheless, no pneumococcal etiology was detected in a recent study of 100 children hospitalized for acute lower respiratory infection.11 Meanwhile, the data is still incomplete and further studies are now actively undergoing in China.
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