LTW Chan, VYH Yu

Abstract

We report two premature infants with respiratory distress syndrome who developed central diabetes insipidus following intracranial insult. There was no midline defect noted both radiologically and clinically. Pituitary hormone profiles were within normal limits in the infants. Intranasal desmopressin was prescribed to both of them with prompt response which was shown by a reduction of urine output and normalization of serum sodium level with urine concentrating ability. The dose and administration method of desmopressin were repeatedly adjusted. Central diabetes insipidus did not resolve even after the complete resolution of intraventricular haemorrhage in one of the babies.

我們報導了兩例呼吸窘迫綜合症的未成熟新生兒，他們都因為顱內損傷發展為中樞性尿崩症。放射診斷及臨床表現均未提示顱腦中部的損傷。垂體激素亦在嬰兒正常值範圍內。經鼻內給予醋酸去胺加壓素，兩個患兒均出現了尿量減少及隨著尿濃縮能力的提高血鈉水平趨於正常的即時反應。醋酸去胺加壓素的給藥劑量和方法均反復給予調整。其中一個顱內出血的患兒即使在病情完全治癒後其尿崩症仍然存在。