Table of Contents

HK J Paediatr (New Series)
Vol 8. No. 1, 2003

HK J Paediatr (New Series) 2003;8:40-42

Case Report

A Baby Girl with Neonatal Thyrotoxicosis and Subsequent Pituitary Hypothyroidism

Lm Wong, K Tse


A baby girl was delivered at 36 weeks of gestation. Antenatally her mother was diagnosed to have thyrotoxicosis in third trimester and was put on propyl-thiouracil for 2 weeks before delivery. Initially the baby had typical biochemical findings of thyrotoxicosis. In subsequent follow up she developed pituitary hypothyroidism. Treatment with L-thyroxine achieved normal serum free thyroxine level and the baby girl enjoyed normal growth and neuro-development during the 2 years of therapy. The case illustrated the need for early detection of neonatal thyrotoxicosis (especially with current or past maternal history of thyrotoxicosis) and the possibility of subsequent pituitary hypothyroidism.

一孕齡 36 週出生之女嬰,其母在孕期後三個月被診斷為甲狀腺素毒症,經 2 週丙基─硫尿嘧啶(propyl-thiouracil)治療後分娩。女嬰出生初期被驗出有典型甲狀腺素毒症的生化指徵,隨後發展到垂體性甲狀腺功能低下。經使用左旋─甲狀腺素(L-thyroxine)治療,一直維持其血清游離甲狀腺素在正常水平, 2 年來小女孩的體格生長及神經系統發育均正常。此病例闡明在臨床工作中需要早期檢測新生兒(特別是母親有近期或過去之甲狀腺素毒症病史)的甲狀腺功能之後和隨後而來的垂體性甲狀腺功能低下。

Keyword : Neonatal thyrotoxicosis; Thyroxine treatment; Transient hypothyroxinaemia



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