Table of Contents

HK J Paediatr (New Series)
Vol 7. No. 1, 2002

HK J Paediatr (New Series) 2002;7:33-38

Original Article

Study on Incidence of Antibiotic Associated Diarrhoea in General Paediatric Ward

CM Hui, K Tse


Objective: To estimate the incidence rate and risk factors of developing Antibiotic Associated Diarrhoea (AAD) in paediatric patients in hospital setting. Design: Retrospective case records review. Setting: General paediatric ward of a regional acute hospital. Methods: Within a one month study period, the case records of all newly admitted paediatric patients with antibiotics prescribed after admission are reviewed. Diarrhoea is defined as loose stools three times or more per day, or watery stool. Patients who had no feature of prior infective gastroenteritis or nosocomial infection and developed diarrhoea after administration of antibiotic will be considered to have AAD. The demographic data of the patients, the duration of diarrhoea and the stool consistency will be recorded. The different classes of antibiotics prescribed will also be reported.Results: 18 out of 171 patients (10.5%) developed AAD and all patients with AAD were less than three years of age. The majority of AAD was mild and self-limiting. The relationships between incidence of AAD and different types of antibiotic prescribed cannot be clearly determined due to small patient number. Conclusion: The impact of the problem cannot be overlooked and further large scale prospective study is warranted to determine the true incidence and risk factors of AAD.

目的:評價住院患兒抗生素相關性腹瀉( AAD)的發病率和危險因素。實驗設計:回顧性病例總結。背景:一家地區性急救醫院的綜合性兒科病房。方法:在為期一個月的研究期間,對入院後使用抗生素的所有新近住院的患兒病例進行總結。腹瀉被定義為稀便每天 3 次或以上,或者水樣便。沒有前驅感染性胃腸炎、或醫源性感染,而在使用抗生素後產生腹瀉的患者被認為患有 AAD。患者的統計學資料、腹瀉病程和大便的黏稠度將被記錄下來。所使用的不同級別的抗生素也要記載。結果:171 名患者中 18 人患 AAD(10.5%),所有 AAD 患者都在 3 歲以下。多數 AAD 為輕度、自限性的。由於病人數量少,AAD 的產生與所使用的不同類型的抗生素之間的相關性不能確定。結論:問題的影響是不容忽視的,需要進一步、大規模的前瞻性研究來明確 AAD 真實的發病率和危險因素。

Keyword : Antibiotic associated diarrhoea; Incidence; Paediatric



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