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HK J Paediatr (New Series)
Vol 28. No. 1,
2023
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HK J Paediatr (New Series) 2023;28:41-45
Case Report
Sublingual Capsular All-trans Retinoic Acid for Induction Treatment of Acute Promyelocytic Leukaemia in a Child
GPY Tong, JKH Chiu, CW Luk, SY Ha Department of Paediatrics, Hong Kong Children’s Hospital, 1 Shing Cheong Road, Kowloon Bay, Kowloon, Hong Kong SAR, China GPY Tong (唐沛容) MBBS CW Luk (陸頌榮) MBBS SY Ha (夏修賢) MBBS Department of Paediatrics, Queen Elizabeth Hospital, 30 Gascoigne Road, Kowloon, Hong Kong SAR, China JKH Chiu (趙嘉豪) MBBS Correspondence to: Dr GPY Tong Email: grace.tong@ha.org.hk Received March 3, 2021
Abstract Oral all-trans retinoic acid (ATRA) is an integral part of acute promyelocytic leukaemia (APL) treatment. However, it poses difficulties for patients who cannot tolerate oral medication. We report a child with APL which was complicated by ruptured acute appendicitis and paralytic ileus. As a result, oral ATRA was administered sublingually during induction. Clinical remission was achieved after induction and the patient went on with subsequent chemotherapy with no relapse for more than 3 years from diagnosis. We reviewed the literature about the necessity of ATRA in APL treatment and how sublingual ATRA was used. Keyword : Acute promyelocytic leukaemia; All-trans-retinoic acid
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