JL Yu, YY Zhang, W Lin, Y Wu, XL Zheng, HB He, PJ Qi, J Fan, SY Cai, RD Zhang, HY Zheng

Abstract

Background: Adopting paediatric-based protocol for adolescent acute lymphoblastic leukaemia (ALL) patients has been reported leading to superior prognosis, however, large group of study in Chinese population has not been documented. Purpose: To analyse the clinical characteristics, prognostic factors and outcome of adolescent patients with newly diagnosed ALL treated with paediatric-based protocol in a tertiary centre in China. Methods: We summarised our data of 121 adolescent ALL (aged 10-16 years) treated with Chinese Children's Leukemia Group (CCLG-ALL 2008) protocol from 2008 to 2013. Results: During 2008-2012, a total of 121 adolescent patients with ALL were enrolled in our study. The 5-year overall survival rate (OS) and event-free survival rate (EFS) was 82.64% and 80.78%, respectively. The 5-year EFS rate was 89.05% in intermediate risk patients, whereas, it was significantly lower for the high risk group (59.54%). High initial leukocyte count (WBC >50 x 10⁹/L), T-immunophenotype, BCR/BAL and poor response to prednisone at Day 8 were associated with inferior prognosis. Conclusions: Adolescent ALL patients achieved satisfactory outcome using paediatric-based protocol of CCLG-ALL 2008.