Table of Contents

HK J Paediatr (New Series)
Vol 27. No. 2, 2022

HK J Paediatr (New Series) 2022;27:126-131

Original Article

Serum Myeloperoxidase, Paraoxonase and Arylesterase Enzymes Levels in Children with Bronchiectasis

MC Kiyak, FU Kahraman, AH Gedik, A Kocyigit, FB Çakir, M Nursoy, E Çakir


Abstract

Background: The aim of this study was to measure the serum levels of myeloperoxidase (MPO), paraoxonase (PON1) and arylesterase (ARE) in paediatric patients with non-cystic fibrosis bronchiectasis (non-CF BE), and to compare these results with healthy controls. Methods: A total of 101 paediatric patients with non-CF BE and 70 age- and sex-matched healthy controls were enrolled into the study between November 2010 and November 2015. The levels of MPO, PON1 and ARE were measured in all participants. Findings: Compared to controls, MPO levels were significantly lower (p=0.001), while PON1 and ARE levels were significantly higher in the patient group (p=0.001). Conclusion: Our study reports that the oxidant and anti-oxidant enzyme levels in non-CF BE differ from healthy controls; thus, suggesting a role in non-CF BE pathophysiology.

Keyword : Arylesterase; Bronchiectasis; Myeloperoxidase; Oxidant; Paraoxonase


 
 

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