Table of Contents

HK J Paediatr (New Series)
Vol 27. No. 1, 2022

HK J Paediatr (New Series) 2022;27:19-24

Original Article

The Clinical Effects of GnRHa in Treating Idiopathic Central Precocious Puberty in Girls

K Yang, HF Zhang, JX Liu, RM Li, LL Zang, YN Zhang, Y Wang, RF Qi


Purpose: This study will explore the clinical effects of the gonadotropin-releasing hormone analogue (GnRHa) to treat girls with idiopathic central precocious puberty (ICPP). Methods: Fifty-four ICPP girls were treated with triptorelin acetate. To evaluate the clinical effects of GnRHa, measurements were taken of the girls' height, weight, ovaries, and uterus before treatment and at 6 and 12 months after treatment. Findings: During the one-year treatment period, the height growth rate slowed in the second half of the year, and the secondary sexual characteristics retracted to varying degrees. Intracavitary ultrasound showed a decrease in the ovary and uterus volumes and in the ovaries' longitudinal diameter, transverse diameter, and anteroposterior diameter and the uterus's transverse diameter. Conclusions: GnRHa can inhibit the development of the gonads and secondary sexual characteristics and induce significant changes in the volume of the ovaries and uterus, longitudinal ovarian diameter, transverse ovarian diameter, anteroposterior ovarian diameter, and transverse uterine diameter.

Keyword : BMI; GnRHa; Idiopathic central precocious puberty in girls; Pelvic ultrasound; Secondary sexual characteristics


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