Table of Contents

HK J Paediatr (New Series)
Vol 26. No. 4, 2021

HK J Paediatr (New Series) 2021;26:197-203

Original Article

IgA Nephropathy Associated with Acute Kidney Injury in Young Patients: The Clinicopathological Features and Risk Factors Analysis

G Huang, H Shen, H Fu


Objective : Little is known about the clinicopathological markers of IgA nephropathy (IgAN) to identify the acute kidney injury (AKI) among young patients. This work aimed to explore the possible risk factors of AKI. Methods: From 2012 to 2017, 110 patients aging from 2.5 to 16 with biopsy-proven primary IgAN were studied in our medical centre. The patients were divided into the AKI group (n=13) and the non-AKI group (n=97). Results: The occurrence of AKI among young patients with IgAN was 11.82% (13/110). Most AKI patients showed more proteinuria higher proneness to hypertension and higher content of uric acid. The proportion of glomeruli with crescents to the normal glomeruli was higher in the AKI group. The multivariate logistic regression analysis suggested that the elevated levels of proteinuria and uric acid might be the risk factors of AKI. Conclusion: AKI was common in young IgAN patients (age 2.5 - 16), who showed more severe clinicopathological symptoms than those without AKI. Some symptoms might be helpful in terms of determining the risk factors of AKI.

Keyword : Acute kidney injury; Heavy proteinuria; IgA nephropathy; Risk factor; Uric acid


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