Table of Contents

HK J Paediatr (New Series)
Vol 26. No. 4, 2021

HK J Paediatr (New Series) 2021;26:219-226

Original Article

Clinical Characteristics and Outcomes of Paediatric Non-tuberculous Mycobacterial Infection: Single Institution Retrospective Review Over Past 20 Years

WYK Chan, PPW Lee, AKS Chiang, DKL Cheuk, SY Ha, PL Ho


Abstract

Non-tuberculous mycobacterial (NTM) infection is uncommon yet clinically significant as it could cause severe morbidity and mortality. This study reviewed all paediatric patients under 20 years of age diagnosed to have NTM infection in Queen Mary Hospital during 1 January 1999 to 30 June 2018. Total 7 patients were identified with median age of diagnosis at 6 years old and median duration of follow up for 30 months. Majority (86%) have underlying comorbidities such as haemic malignancies or history of stem cell transplantation. Clinical manifestations varied from lymphadenitis, pulmonary infection, osteomyelitis, arthritis to systemic bacteraemia. Infective agents include Mycobacterium fortuitum, M. abscessus and M. chelonae. Mortality rate was high (29%). High index of suspicion and early recognition of NTM infection is important especially in immunocompromised and at-risk individuals. Prompt administration of appropriate therapy improves patient outcomes. Multidisciplinary collaboration is crucial. Treatment could be difficult and prolonged. Drug-related toxicities are common.

Keyword : Diagnosis; Morbidity; Nontuberculous mycobacteria; Therapeutics


 
 

This web site is sponsored by Johnson & Johnson (HK) Ltd.
©2022 Hong Kong Journal of Paediatrics. All rights reserved. Developed and maintained by Medcom Ltd.