Table of Contents

HK J Paediatr (New Series)
Vol 26. No. 1, 2021

HK J Paediatr (New Series) 2021;26:34-37

Case Report

Safety and Effectiveness of Herbal Medicine Administered from the Early Neonatal Period in Two Neonates with Congenital Cystic Lymphatic Malformations

S Hashimoto


There are various treatments of lymphatic malformations. Herbal medicine (TJ-28) is effective for treating lymphatic malformations. TJ-28 was administered from the early neonatal period to two neonates with lymphatic malformations at birth. In Case 1, a lymphatic malformation on the neck at birth was treated with TJ-28 from 5 days old. The lymphatic malformation was greatly reduced, but there was a mild transient elevation in liver aminotransferases levels, which were unlikely to be related to TJ-28. In Case 2, a lymphatic malformation in the femur at birth was treated with TJ-28 from 3 days old. There were no adverse events, but the lymphatic malformation was not reduced until 7 months old. TJ-28 administered from the early neonatal period showed no serious adverse events and it was effective in one of two cases. Therefore, TJ-28 may be a treatment for neonates with lymphatic malformations when surgery or sclerotherapy is difficult.

Keyword : Herbal medicine; Lymphatic malformation; Neonate; Safety


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