Table of Contents

HK J Paediatr (New Series)
Vol 24. No. 4, 2019

HK J Paediatr (New Series) 2019;24:240-244

Case Report

Arterial and Venous Thrombosis in a Chinese Boy with Hypereosinophilic Syndrome

CH Wong, SY Ha, PCY Chong, JS Rosa Duque


A 16-year-old Chinese boy presented with multiple tender subcutaneous nodules and erythematous pruritic rashes over bilateral lower limbs. Investigation showed markedly elevated circulating eosinophils (7.35x109/L) and positive lupus anticoagulant. Doppler ultrasound and positron emission tomography scan revealed extensive venous thromboses and arterial insufficiency. The diagnosis of idiopathic hypereosinophilic syndrome with multiple end-organ involvement was established after exclusion of possible infectious, allergic and oncologic causes. Symptoms resolved after treatment that included low-molecular-weight heparin, corticosteroid and azathioprine. Here we describe the variable manifestations of hypereosinophilic syndrome and its associated features.


Keyword : Hypereosinophilia; Lupus anticoagulant; Thrombosis; Vasculitis



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