Table of Contents

HK J Paediatr (New Series)
Vol 24. No. 4, 2019

HK J Paediatr (New Series) 2019;24:240-244

Case Report

Arterial and Venous Thrombosis in a Chinese Boy with Hypereosinophilic Syndrome
動脈和靜脈血栓形成見於嗜酸細胞增多綜合徵華裔男孩一例

CH Wong, SY Ha, PCY Chong, JS Rosa Duque


Abstract

A 16-year-old Chinese boy presented with multiple tender subcutaneous nodules and erythematous pruritic rashes over bilateral lower limbs. Investigation showed markedly elevated circulating eosinophils (7.35x109/L) and positive lupus anticoagulant. Doppler ultrasound and positron emission tomography scan revealed extensive venous thromboses and arterial insufficiency. The diagnosis of idiopathic hypereosinophilic syndrome with multiple end-organ involvement was established after exclusion of possible infectious, allergic and oncologic causes. Symptoms resolved after treatment that included low-molecular-weight heparin, corticosteroid and azathioprine. Here we describe the variable manifestations of hypereosinophilic syndrome and its associated features.

一例16歲男孩,表現為多發柔軟皮下結節和雙側下肢紅斑性瘙癢性皮疹。檢查顯示迴圈嗜酸細胞顯著升高(7.35x109/L)和狼瘡抗凝物陽性。多普勒超聲和正電子發射斷層掃描顯示廣泛靜脈血栓形成和動脈灌注不足。在剔除可能受感染、過敏和腫瘤等各個病因後,確定為特發性嗜酸細胞增多綜合徵伴多發器官受累。經過低份子肝素、糖皮質激素和硫唑嘌呤治療後症狀緩解。在此作者描述嗜酸細胞增多綜合徵的多種臨床表現和相關特徵。

Keyword : Hypereosinophilia; Lupus anticoagulant; Thrombosis; Vasculitis

關鍵詞:嗜酸細胞增多綜合徵、狼瘡抗凝物、血栓形成、脈管炎

 
 

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