FWT Cheng, GKS Lam, TTW Chow, MMK Shing, V Lee, CK Li

Abstract

We report the clinical course and treatment outcome of 7 patients with therapy-related myeloid neoplasm in the past 32 years. The primary conditions included both solid tumours and leukaemia. The time interval between onset of primary disease and therapy-related neoplasm ranged from 1.2 years to 4.4 years. In contrary to the reported high treatment-related mortality and morbidity, with fludarabine-based salvage chemotherapy, stringent supportive care and early allogeneic stem cell transplantation as consolidative therapy, long term survival can be achieved in 5 out of 7 patients. Long-term follow-up is warranted for survivors with oncology patients who received chemotherapy.