Y Kashiwagi, S Go, S Nishimata, H Kawashima

Abstract

Leukocytapheresis (LCAP) therapy was administered to 2 patients with steroid-resistant ulcerative colitis (UC). In one patient, serum levels of cytokines decreased and clinical improvement was observed after each LCAP therapy session. In the other patient who was infected with cytomegalovirus (CMV), serum levels of cytokines did not decrease progressively and minimal clinical improvement was observed. CMV infection is considered to be an important exacerbating factor in patients with UC. Therefore, unaltered cytokine levels in patients receiving LCAP therapy may be associated with refractory UC.

白細胞清除治療（LCAP）用於2位皮質激素抵抗的潰瘍性結腸炎（UC）病者。每一LCAP治療期後，其中一位病者的血清細胞因數水平下降，臨床情況改善。另一位元有過往巨細胞病毒感染的病者中，血清細胞因數水平並無進行性降低，臨床情況改善輕微。巨細胞病毒感染被認為是UC病者的一個重要惡化因素。因此，接受LCAP治療的病者無細胞因數水平改變，可能與難治性UC相關。