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HK J Paediatr (New Series)
Vol 22. No. 1,
2017
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HK J Paediatr (New Series) 2017;22:39-42
Case Report
Cytokine Profiling Demonstrated Unaltered Serum Cytokine Levels in a Cytomegalovirus-infected Patient Treated by Leukocytapheresis
Y Kashiwagi, S Go, S Nishimata, H Kawashima Department of Pediatrics, Tokyo Medical University, 6-7-1 Nishishinjuku, Shinjuku-ku, Tokyo, Japan
Y Kashiwagi MD, PhD
S Go MD, PhD
S Nishimata MD, PhD
H Kawashima MD, PhD Correspondence to: Dr Y Kashiwagi Received November 7, 2015
Abstract Leukocytapheresis (LCAP) therapy was administered to 2 patients with steroid-resistant ulcerative colitis (UC). In one patient, serum levels of cytokines decreased and clinical improvement was observed after each LCAP therapy session. In the other patient who was infected with cytomegalovirus (CMV), serum levels of cytokines did not decrease progressively and minimal clinical improvement was observed. CMV infection is considered to be an important exacerbating factor in patients with UC. Therefore, unaltered cytokine levels in patients receiving LCAP therapy may be associated with refractory UC. Keyword : Cytokine; Cytomegalovirus; Leukocytapheresis; Ulcerative colitis
Abstract in Chinese
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