S Chandra, R Kumar

Abstract

Aim: West syndrome is an age dependent epileptic encephalopathy and there is paucity of data regarding its clinic-aetiological profile. Methods: We studied 76 patients of West syndrome, carrying out a detailed aetiological work-up of all. Results: Majority of patients were males (57/76), having flexor infantile spasms (66/76), usually occurring in series (45/76) and seen mostly on awakening (63/76). We found a good seizure outcome in 40.8% and a good development outcome in 8.1% cases. Interpretation: West syndrome in India also, has almost a similar clinico-etiological profile as in other parts of the world where it has been studied.

目的：West 綜合徵是一種年齡依賴性癲癇性腦病。缺乏臨床-病因分析的資料。方法：我們研究了76個West 綜合徵的病人，並進行了詳細的病因檢查。結果：大部份病人為男性患兒（57/76）；有屈曲型痙攣發作（66/76）；通常成串發作（45/76）；大部份病人在清醒期發作（63/76）。我們發現40.8%病人驚厥預後良好，8.1%病人發育預後良好。說明：印度北部和世界其他地方報導的West 綜合徵一樣具有相似的臨床徵狀和病因。