B Ozhan, H Evrengul, S Yilmaz Agladioglu, S Ümit Yasar, S Demir

Abstract

Objectives : An optimal vitamin D status is important for the growth and development of bones in children and adolescents. We aimed to determine the frequencies of 25-hydroxyvitamin D (25(OH)D) deficiency and insufficiency in children and adolescents. Patients: A total of 556 children aged 0 to 18 years were included in the study. Serum 25(OH)D, calcium, phosphorous and alkaline phosphatase levels were measured. Results: Prevalence of low vitamin D status (<30.0 ng/mL) was 63.5% for children aged 0 to 18 years; 219 children (39.3%) had vitamin D deficiency (<20 ng/mL), while 134 of them (24.10%) had vitamin D insufficiency (20 ng/mL ?insufficient <30 ng/mL). The prevalence of vitamin D deficiency was higher among girls compared with boys, in adolescents compared with childhood stages and in autumn compared with other seasons. Conclusions: 25(OH)D deficiency/insufficiency was found to be very common in the studied population. Routine screening and supplementation to prevent vitamin D deficiency in at-risk groups during winter and autumn months when vitamin D synthesis is scarce, may be required.

目的：良好維生素D狀態對兒童和青少年的骨骼生長發育是重要的。我們目的是檢測兒童和青少年中25-羥維生素D（25(OH)D）缺乏和不足的患病頻率。病人：研究涉及0-18歲兒童／青少年共計586名。對血漿25(OH)D、鈣、磷和鹼性磷酸酶水準進行測量。結果：>0-18歲兒童／青少年低維生素D（< 30.0 ng/mL）患病頻率為63.5%。219名兒童（39.3%）為維生素D缺乏（<20 ng/mL），134名兒童為維生素D不足（20 ng/mL≤不足 <30 ng/mL）。維生素D缺乏的患病頻率女童高於男童、青少年期高於兒童期、秋季高於其他季節。結論：25(OH)D缺乏／不足在研究人群中十分常見。可能需要對高危群組進行常規篩查，在維生素D合成稀少的秋冬季進行補充以預防維生素D缺乏。