LJ Yu, H Wang, H Liang, LL Guo

Abstract

Objective: This study aims to investigate the effects of vitamin D and alkaline phosphatase (AKP) on height. Method: 1887 healthy children were enrolled from May 2014 to December 2014 for the detection of height, AKP, 25(OH)-vitamin D3 [25(OH)D], and serum levels of Calcium (Ca) and Phosphorus (P) at 3 different time points (baseline, 3-month and 6-month). In accordance with the growth speed, the children were divided into the low-speed group (<1 cm/3 months), the middle-speed group (1~2 cm/3 months) and the high-speed group (>2 cm/3 months) to compare the differences of the above indicators among the groups. Results: The enrolled children all had normal serum Ca, and the calcium-phosphorus product was >40, while 98.5% children exhibited the increased serum phosphorus. The high-speed group exhibited significantly increased AKP concentration, which was statistically significant with the other two groups (P<0.05); and the 25-(OH)-VitD3 levels of all groups were low and had no significant difference. Conclusions: The children enrolled had normal serum Ca, but the low 25(OH)D level suggested vitamin D deficiency. The high concentration of AKP signified rapid growth.