Table of Contents

HK J Paediatr (New Series)
Vol 20. No. 4, 2015

HK J Paediatr (New Series) 2015;20:242-245

Invited Article

The Perinatal Microbiome: Implications for Future Health
圍產期微生物:對於兒童未來健康的影響

J Neu


Abstract

The importance of the association between the human host and microbes during early life is receiving increased attention because this relationship is crucial to subsequent health. Recent studies have demonstrated that the maternal-fetal unit is not sterile and microbes are present in placenta, amniotic fluid, as well as the babies' first stools, the meconium. The interactions between the mother, fetus and the microbes continue after the infant leaves the uterus via breast-feeding by the mother, as well as close postnatal contact. We are just beginning to discover that perturbations of this relationship by antibiotics and various other drugs, maternal and neonatal diet, may result in life-long consequences. This article offers a brief introduction and should provide an appreciation of these early host-microbial interactions as they pertain to subsequent health and disease.

在人類早期的宿主和微生物之間的關係,其重要性正在受到越來越多的關注,因為這種關係對於人類之後的健康至為重要。最近的研究已經表明,母親-胎兒單元並不是無菌的,微生物存在於胎盤、羊水、以及嬰兒的第一次胎糞。在胎兒離開子宮後,通過哺乳及產後緊密接觸,母親、胎兒和微生物之間的關係繼續存在。我們剛剛發現抗生素、其他藥品、孕產婦及新生兒的飲食,對於這種關係的的干擾可能會導致影響終生的後果。本文提供了一個簡單的介紹,強調了宿主-微生物關係的重要性,因為其對於兒童日後的健康和疾病有密切的關係。

Keyword : Development; Fetus; Microbiome; Neonate

關鍵詞:發展、新生兒、微生物、生長發育

 
 

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