Table of Contents

HK J Paediatr (New Series)
Vol 20. No. 2, 2015

HK J Paediatr (New Series) 2015;20:71-79

Original Article

Prenatal Iron Deficiency and Auditory Brainstem Responses at 3 and 10 Months: A Pilot Study
對胎兒期出現鐵缺乏對嬰兒3個月大和10個月大時腦幹聽力誘發反應關係的影響:一項前瞻性研究

J Lou, X Mai, B Lozoff, PR Kileny, BT Felt, Z Zhao, J Shao


Abstract

Purpose: To examine whether prenatal iron deficiency delays auditory brainstem response (ABR) maturation in infancy. Methods: One hundred and fifteen full-term healthy Chinese infants with maternal and cord blood haemoglobin and serum ferritin determinations were recruited into this study. Forty-eight infants received ABR testing at 3 months, and 45 infants were tested at 10 months. Comparison of the ABR variables were made between infants with and those without evidence of prenatal iron deficiency (maternal 3rd trimester haemoglobin <110 g/L, cord blood ferritin <75 μg/L); or anaemia at 10 months (haemoglobin <110 g/L). Results: Latencies for wave V and wave III-V and I-V intervals were prolonged at 3 months in infants of anaemic mothers (effect sizes 1.02-1.19 SD). At 10 months, infants with low cord blood serum ferritin (indicating low iron stores at birth) showed longer wave I latency and possibly wave V latency also, besides demonstrating a smaller wave V amplitude (effect sizes 0.58-0.62 SD). Infants with low ferritin at birth and anemia at 10 months had longer wave III-V latency than other groups. Conclusion: In full-term healthy infants, prenatal iron deficiency appears to have adverse effects on the developing central nervous system and auditory system as assessed by ABRs at 3 and/or 10 months.

目的:研究胎兒期鐵缺乏是否會延遲嬰兒腦幹聽力誘發反應(ABR)的成熟。方法:本研究包括115名足月健康中國嬰兒,以及其孕母和臍帶血血紅蛋白和血清鐵蛋白的檢測結果。48名嬰兒在3個月大時接受ABR檢測,45例嬰兒在10個月大時接受該檢測。對伴有或是不伴有胎兒期鐵缺乏徵狀(孕母孕早期三個月血紅蛋白<110 g/L,臍血血清鐵<75 µg/L),或是在10月大時出現貧血(血紅蛋白<110 g/L)的嬰兒分組進行ABR差異的比較。結果:孕母貧血的嬰兒在3個月大時V波延遲, III-V間隔和I-V間隔延長(效應量1.02-1.19SD)。在10個月大時,低臍血血清鐵蛋白(提示出生時鐵儲存低)的嬰兒除了提示更小的V波振幅(效應量 0.58-0.62SD)之外,還顯示較長的I波延遲和同時可能存在的V波延遲。出生時鐵蛋白較低和10月大時出現貧血的嬰兒,較對照組有更長的 III-V波延遲。結論:在足月健康的嬰兒中,通過3月大和10月大時ABRs檢測發現,孕期鐵缺乏可能對中樞神經系統和聽覺系統發育有不良的影響。

Keyword : Auditory brainstem response; Central nervous system; Iron deficiency; Myelination; Prenatal

關鍵詞:腦幹聽力誘發反應、中樞神經系統、鐵缺乏、髓鞘、胎兒期

 
 

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