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Original Article Serum Vitamin B12 Status in Children with Familial Mediterranean Fever Receiving Colchicine Treatment 對秋水仙堿治療家族性地中海熱兒童後血清維生素B12水平的研究 R Yilmaz, S Ozer, H Ozyurt, U Erkorkmaz Abstract Aims: The aim of this study was to determine the effect of colchicine on serum vitamin B12 status in children with Familial Mediterranean Fever (FMF). Settings and Design: The Tel Hashomer criteria had been used to establish the diagnosis of FMF. Colchicine treatment was initiated by age based dosage schedule to each patient. Methods and Material: This study was cross sectional. Serum vitamin B12 levels were measured before and during colchicine treatment in 42 children with FMF. Results: Twenty- two girls and 20 boys, with a mean age of 11.7±0.5 years, were included in the study. The mean duration of colchicine treatment was 2.5±2.6 years. The daily colchicine doses ranged between 0.0077 to 0.0741 mg/kg. There was a significant difference between first and control visit mean serum vitamin B12 levels, 418 pg/ml and 240 pg/ml respectively (p<0.0001). Control visit serum vitamin B12 levels had no statistically important correlation to the duration of colchicine treatment (r=-0.287, p=0.065) but there was a significant correlation to the daily colchicine doses. (r=+0.349, p=0.025) Conclusions: The present study showed that long term administration of colchicine led to a decrease (subnormal) in the serum vitamin B12 levels. Therefore, serum vitamin B12 levels should be evaluated regularly in FMF patients receiving colchicine treatment. 目的:本研究主要目的是確定秋水仙堿對於患有家族性地中海熱(FMF)的兒童血清維生素B12水平的影響。研究設計:本研究根據Tel Hashomer 診斷標準對FMF進行診斷,隨後按病人的年齡進行相應劑量的秋水仙堿治療。方法及材料:本研究採用橫斷面分析,檢測了42例FMF病人在用藥前及用藥中血清維生素B12的水平。結果:本研究對22例女童以及20例男童(平均年齡11.7±4.5)進行了分析,秋水仙堿的平均治療療程為2.5 ?.6年,每日秋水仙堿治療劑量介於0.0077 至0.0741 mg/kg之間。分析發現首次就診時與隨診時的血清維生素B12水平存在顯著性差異,分別為418 pg/ml與240 pg/ml(p<0.0001)。而隨診時血清維生素B12的水平與治療的療程並無重要的統計學相關性(r=-0.287, p=0.065),但與每日秋水仙堿劑量存在有重要的統計學相關性(r=+0.349, p=0.025)。結論:本研究提示長期使用秋水仙堿可導致血清維生素B12水平減低(低於正常水平)。因此,對於接受秋水仙堿治療FMF病人應進行規律的維生素B12水平的檢測。 Keyword : Colchicine; Familial Mediterranean fever; Vitamin B12 關鍵詞:秋水仙堿、家族性地中海熱、維生素B12
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