Table of Contents

HK J Paediatr (New Series)
Vol 24. No. 4, 2019

HK J Paediatr (New Series) 2019;24:184-191

Original Article

Overview of Treatment of Childhood Acute Lymphoblastic Leukaemia in Hong Kong
香港兒童急性淋巴細胞白血病治療概況

FWT Cheng, GKS Lam, DKL Cheuk, CW Luk, CH Li, SC Ling, AKS Chiang, MHL Ng, CK Li; On behalf of the Hong Kong Paediatric Haematology and Oncology Study Group


Abstract

In this report, we review the landmark and achievement in treatment of acute lymphoblastic leukaemia (ALL) in Hong Kong over the past 35 years. With the joint efforts from different professionals, lining up with parties in various specialties not only in Hong Kong, but also in mainland and worldwide, we are achieving our goals in enhancing the event-free survival of Hong Kong children with ALL. Through collaboration with major childhood cancer networks in joining international trials 17 years ago and in the last 10 years, we started collaboration with working group in China and conducting national multi-center studies. We worked through different treatment protocols with advancement in treatment outcome. The 5-year event-free survival of children with ALL in Hong Kong has improved from 65% to now 87%. The next step will be the advance in cancer genetics. This serves a dual purpose of better categorising of ALL subtypes with different prognostic significance and also identifying potential druggable targets for ALL with known adverse outcome. With the translocation of territory-wide paediatric oncology service to Hong Kong Children's Hospital, it opens a new page and a unified platform for basic and clinical research in children with cancers. This will bring further achievement in care of children who suffer from cancers in Hong Kong.

在此報告中,團隊綜述過去35年香港急性淋巴細胞白血病(ALL)治療中的里程碑和成就。綜合多個學科專業的共同努力,來自香港、大陸和世界各地的專家共同參與,團隊不斷邁向香港ALL病童的無病生存率的目標。通過與主流兒童癌症網路的協作,17年前加入國際臨床試驗,近10年團隊開始與中國的協作網合作,並同時引入國際多中心研究。團隊因應病孩的病情而使用不同的治療方案,進一步提升療效。香港ALL 病童的5年無病生存率從65%提高至目前的87%。下一步發展將在癌症基因學的研究及運用,這既為不同預後情況的ALL亞型病童進行更好分類,並同時為已知療效不佳的ALL兒童尋找潛在的藥物作用靶點。隨著香港各個兒童腫瘤服務單位集中在香港兒童醫院運作,這為兒童腫瘤的基礎和臨床研究開啟新的篇章及提供一體化平臺,將為香港癌症病童的醫療帶來新的成就。

Keyword : Acute Lymphoblastic Leukaemia; Treatment

關鍵詞:急性淋巴細胞白血病、治療

 
 

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