S Hashimoto

Abstract

There are various treatments of lymphatic malformations. Herbal medicine (TJ-28) is effective for treating lymphatic malformations. TJ-28 was administered from the early neonatal period to two neonates with lymphatic malformations at birth. In Case 1, a lymphatic malformation on the neck at birth was treated with TJ-28 from 5 days old. The lymphatic malformation was greatly reduced, but there was a mild transient elevation in liver aminotransferases levels, which were unlikely to be related to TJ-28. In Case 2, a lymphatic malformation in the femur at birth was treated with TJ-28 from 3 days old. There were no adverse events, but the lymphatic malformation was not reduced until 7 months old. TJ-28 administered from the early neonatal period showed no serious adverse events and it was effective in one of two cases. Therefore, TJ-28 may be a treatment for neonates with lymphatic malformations when surgery or sclerotherapy is difficult.