Table of Contents

HK J Paediatr (New Series)
Vol 25. No. 4, 2020

HK J Paediatr (New Series) 2020;25:222-231

Original Article

Efficacy of Postoperative High-dose Steroids in Infants with Biliary Atresia: A Meta Analysis

XT Dong, L Huang, DQ Mao, H Yang


Abstract

Purpose: To evaluate whether high vs low-dose steroids or non-steroid improve the clearance rates of jaundice, cholangitis, and survival rates with the native liver in biliary atresia (BA) after Kasai portoenterostomy. Methods: Potential prospective and retrospective controlled trials were extracted from the computer database. Odds ratios (OR) with 95% confidence intervals (CI) were calculated for the clearance rates of jaundice, cholangitis and survival rates with native liver. Findings: The pooled OR significantly favour high-dose steroids (the cumulative dosage of prednisolone over 80 mg/kg) over low-dose steroids (the cumulative dosage of prednisolone less than 43 mg/kg) (1.804; 95%CI: 1.286, 2.531; P=0.001) or non-steroid (2.236; 95% CI: 1.122, 4.458; P=0.022) in the clearance rates of jaundice. Conclusion: High-dose steroids in postoperative BA improve the clearance rates of jaundice compared with low-dose steroids and non-steroid at a follow up of 6 months.

Keyword : Cholangitis; Jaundice; Kasai portoenterostomy; Steroids; Survival rates


Abstract in Chinese

 
 

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